2o39: Difference between revisions
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[[Image:2o39.gif|left|200px]] | [[Image:2o39.gif|left|200px]] | ||
'''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)''' | {{Structure | ||
|PDB= 2o39 |SIZE=350|CAPTION= <scene name='initialview01'>2o39</scene>, resolution 2.85Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= | |||
|GENE= PIV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35262 Human adenovirus type 35p]), CD46, MCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2O39 is a [ | 2O39 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA]. | ||
==Reference== | ==Reference== | ||
Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:[http:// | Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17220899 17220899] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human adenovirus type 35p]] | [[Category: Human adenovirus type 35p]] | ||
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[[Category: virus receptor complex]] | [[Category: virus receptor complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:54:32 2008'' | ||
Revision as of 18:54, 20 March 2008
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| , resolution 2.85Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | PIV (Human adenovirus type 35p), CD46, MCP (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)
OverviewOverview
Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.
DiseaseDisease
Known diseases associated with this structure: Hemolytic-uremic syndrome OMIM:[120920], Measles, susceptibility to OMIM:[120920]
About this StructureAbout this Structure
2O39 is a Protein complex structure of sequences from Homo sapiens and Human adenovirus type 35p. Full crystallographic information is available from OCA.
ReferenceReference
Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:17220899
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