2j69: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2j69]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_punctiforme Nostoc punctiforme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J69 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2j69]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_punctiforme Nostoc punctiforme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J69 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j68|2j68]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j68|2j68]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j69 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j69 RCSB], [http://www.ebi.ac.uk/pdbsum/2j69 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j69 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j69 RCSB], [http://www.ebi.ac.uk/pdbsum/2j69 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Nostoc punctiforme]] | [[Category: Nostoc punctiforme]] | ||
[[Category: Low, H H | [[Category: Low, H H]] | ||
[[Category: Lowe, J | [[Category: Lowe, J]] | ||
[[Category: Dynamin]] | [[Category: Dynamin]] | ||
[[Category: Fzl]] | [[Category: Fzl]] | ||
Revision as of 19:21, 19 January 2015
BACTERIAL DYNAMIN-LIKE PROTEIN BDLPBACTERIAL DYNAMIN-LIKE PROTEIN BDLP
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedDynamins form a superfamily of large mechano-chemical GTPases that includes the classical dynamins and dynamin-like proteins (DLPs). They are found throughout the Eukarya, functioning in core cellular processes such as endocytosis and organelle division. Many bacteria are predicted by sequence to possess large GTPases with the same multidomain architecture that is found in DLPs. Mechanistic dissection of dynamin family members has been impeded by a lack of high-resolution structural data currently restricted to the GTPase and pleckstrin homology domains, and the dynamin-related human guanylate-binding protein. Here we present the crystal structure of a cyanobacterial DLP in both nucleotide-free and GDP-associated conformation. The bacterial DLP shows dynamin-like qualities, such as helical self-assembly and tubulation of a lipid bilayer. In vivo, it localizes to the membrane in a manner reminiscent of FZL, a chloroplast-specific dynamin-related protein with which it shares sequence similarity. Our results provide structural and mechanistic insight that may be relevant across the dynamin superfamily. Concurrently, we show compelling similarity between a cyanobacterial and chloroplast DLP that, given the endosymbiotic ancestry of chloroplasts, questions the evolutionary origins of dynamins. A bacterial dynamin-like protein.,Low HH, Lowe J Nature. 2006 Dec 7;444(7120):766-9. Epub 2006 Nov 22. PMID:17122778[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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