2ntr: Difference between revisions

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OCA

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-[[Image:2ntr.jpg|left|200px]]<br /><applet load="2ntr" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2ntr.jpg|left|200px]]
-caption="2ntr, resolution 1.80&Aring;" />
-'''Crystal structure of Human Bace-1 bound to inhibitor'''<br />
+ {{Structure
+|PDB= 2ntr |SIZE=350|CAPTION= <scene name='initialview01'>2ntr</scene>, resolution 1.80&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=L00:(2R)-2-(5-{3-chloro-6-((2-methoxyethyl){[(1S,2S)-2-methylcyclopropyl]methyl}amino)-2-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3,4-oxadiazol-2-yl)-1-phenylpropan-2-amine'>L00</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]
+|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Crystal structure of Human Bace-1 bound to inhibitor'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-NTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=L00:'>L00</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTR OCA].
+NTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTR OCA].
 ==Reference==
-Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites., McGaughey GB, Colussi D, Graham SL, Lai MT, Munshi SK, Nantermet PG, Pietrak B, Rajapakse HA, Selnick HG, Stauffer SR, Holloway MK, Bioorg Med Chem Lett. 2007 Feb 15;17(4):1117-21. Epub 2006 Nov 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17112725 17112725]
+Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites., McGaughey GB, Colussi D, Graham SL, Lai MT, Munshi SK, Nantermet PG, Pietrak B, Rajapakse HA, Selnick HG, Stauffer SR, Holloway MK, Bioorg Med Chem Lett. 2007 Feb 15;17(4):1117-21. Epub 2006 Nov 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17112725 17112725]
 [[Category: Homo sapiens]]
 [[Category: Memapsin 2]]
@@ Line 20: / Line 29: @@
 [[Category: hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:10:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:51:02 2008''