Binding site of AChR: Difference between revisions
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The nicotinic acetylcholine receptor(AChR) is a ligand gated ion channel activated by binding of acetylcholine. The α-Neurotoxins such as [http://en.wikipedia.org/wiki/Alpha-Bungarotoxin α-bungarotoxin] (α-BTX)can compete antagonists of acetylcholine for its site. So study the binding site of AChR is very important for the development of antidotesagainstα-BTX poisoning as well as drugs against, like [http://en.wikipedia.org/wiki/Alzheimer's_disease Alzheimer's disease] and [http://en.wikipedia.org/wiki/Nicotine nicotine addiction]. | The nicotinic acetylcholine receptor(AChR) is a ligand gated ion channel activated by binding of acetylcholine. The α-Neurotoxins such as [http://en.wikipedia.org/wiki/Alpha-Bungarotoxin α-bungarotoxin] (α-BTX)can compete antagonists of acetylcholine for its site. So study the binding site of AChR is very important for the development of antidotesagainstα-BTX poisoning as well as drugs against, like [http://en.wikipedia.org/wiki/Alzheimer's_disease Alzheimer's disease] and [http://en.wikipedia.org/wiki/Nicotine nicotine addiction]. | ||
The X-ray structure of AChR has not yet been solved since its hydrophobic character hampers its successful crystallization. So in this page,<ref>PMID:11683996</ref> We will use a complex of α-bungarotoxinwith a high affinity 13-residue peptide that is homologous to the αsubunit of AChR to study the AChR binding site in general. We also will present the [http://proteopedia.org/wiki/index.php/Acetylcholine_binding_protein Acetylcholine binding protein] and the general [http://proteopedia.org/wiki/index.php/4hfi pentameric ligand gated ion channels] to help you understand this kind of structure and their function. | |||
== Pentameric ligand-gated ion channel == | == Pentameric ligand-gated ion channel == | ||
Pentameric ligand gated ion channels(<scene name='68/688431/Plgics/1'>pLGICs</scene>), or [http://en.wikipedia.org/wiki/Cys-loop_receptors Cys-loop receptors],mediate rapid chemical transmission of signals. Nicotinic acetylcholine receptor is a kind of pentameric ligand gated ion channels. So at first of this page, we introduce some facts of the pentameric ligand gated ion channels, which will help us to understand the structure and function of AChR. | Pentameric ligand gated ion channels(<scene name='68/688431/Plgics/1'>pLGICs</scene>), or [http://en.wikipedia.org/wiki/Cys-loop_receptors Cys-loop receptors],mediate rapid chemical transmission of signals. Nicotinic acetylcholine receptor is a kind of pentameric ligand gated ion channels. So at first of this page, we introduce some facts of the pentameric ligand gated ion channels, which will help us to understand the structure and function of AChR. | ||