2jso: Difference between revisions

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Revision as of 18:44, 20 March 2008

File:2jso.gif

Gene:

pmrD (Escherichia coli)

Coordinates:

save as pdb, mmCIF, xml

Antimicrobial resistance protein

OverviewOverview

PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosphorylation, and promotes the transcription of PmrA-activated genes responsible for polymyxin resistance. PmrD is the first protein identified to mediate the connectivity between two TCSs by protecting the phosphorylated response regulator of the downstream TCS. PmrD shows no homology to proteins with known structures. We present here the solution structure of PmrD from Escherichia coli, the first three-dimensional structure of the PmrD family. Our study provides the structural basis of the novel interacting mechanism of bacterial two-component signal-transduction systems.

About this StructureAbout this Structure

2JSO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

First structure of the polymyxin resistance proteins., Fu W, Yang F, Kang X, Zhang X, Li Y, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Oct 5;361(4):1033-7. Epub 2007 Aug 2. PMID:17686460

Page seeded by OCA on Thu Mar 20 17:44:46 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2jso.gif|left|200px]]<br /><applet load="2jso" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2jso.gif|left|200px]]
-caption="2jso" />
-'''Antimicrobial resistance protein'''<br />
+ {{Structure
+|PDB= 2jso |SIZE=350|CAPTION= <scene name='initialview01'>2jso</scene>
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= pmrD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+}}
+'''Antimicrobial resistance protein'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-JSO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA].
+JSO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA].
 ==Reference==
-First structure of the polymyxin resistance proteins., Fu W, Yang F, Kang X, Zhang X, Li Y, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Oct 5;361(4):1033-7. Epub 2007 Aug 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17686460 17686460]
+First structure of the polymyxin resistance proteins., Fu W, Yang F, Kang X, Zhang X, Li Y, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Oct 5;361(4):1033-7. Epub 2007 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17686460 17686460]
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
@@ Line 20: / Line 29: @@
 [[Category: transcription]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:05:42 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:44:46 2008''