2dil: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dil]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DIL FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dil]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DIL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PSTPIP1, CD2BP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PSTPIP1, CD2BP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dil OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dil RCSB], [http://www.ebi.ac.uk/pdbsum/2dil PDBsum], [http://www.topsan.org/Proteins/RSGI/2dil TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dil OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dil RCSB], [http://www.ebi.ac.uk/pdbsum/2dil PDBsum], [http://www.topsan.org/Proteins/RSGI/2dil TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/PPIP1_HUMAN PPIP1_HUMAN]] Defects in PSTPIP1 are the cause of PAPA syndrome (PAPAS) [MIM:[http://omim.org/entry/604416 604416]]; also known as pyogenic sterile arthritis, pyoderma gangrenosum and acne or familial recurrent arthritis (FRA). PAPAS is characterized by autosomal dominant inheritance of early onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction.<ref>PMID:14595024</ref> <ref>PMID:11971877</ref> | [[http://www.uniprot.org/uniprot/PPIP1_HUMAN PPIP1_HUMAN]] Defects in PSTPIP1 are the cause of PAPA syndrome (PAPAS) [MIM:[http://omim.org/entry/604416 604416]]; also known as pyogenic sterile arthritis, pyoderma gangrenosum and acne or familial recurrent arthritis (FRA). PAPAS is characterized by autosomal dominant inheritance of early onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction.<ref>PMID:14595024</ref> <ref>PMID:11971877</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Inoue, M | [[Category: Inoue, M]] | ||
[[Category: Kigawa, T | [[Category: Kigawa, T]] | ||
[[Category: Koshiba, S | [[Category: Koshiba, S]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Tochio, N | [[Category: Tochio, N]] | ||
[[Category: Yokoyama, S | [[Category: Yokoyama, S]] | ||
[[Category: Yoneyama, M | [[Category: Yoneyama, M]] | ||
[[Category: Cd2-binding protein 1]] | [[Category: Cd2-binding protein 1]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
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[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Pest phosphatase-interacting protein 1]] | [[Category: Pest phosphatase-interacting protein 1]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Sh3 domain]] | [[Category: Sh3 domain]] | ||
Revision as of 19:12, 15 January 2015
Solution structure of the SH3 domain of the human Proline-serine-threonine phosphatase-interacting protein 1Solution structure of the SH3 domain of the human Proline-serine-threonine phosphatase-interacting protein 1
Structural highlights
Disease[PPIP1_HUMAN] Defects in PSTPIP1 are the cause of PAPA syndrome (PAPAS) [MIM:604416]; also known as pyogenic sterile arthritis, pyoderma gangrenosum and acne or familial recurrent arthritis (FRA). PAPAS is characterized by autosomal dominant inheritance of early onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction.[1] [2] Function[PPIP1_HUMAN] Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2.[3] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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