Sandbox Reserved 957: Difference between revisions
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For each inhibitor, <scene name='60/604476/H_loop/1'>H-loop</scene> take a different and originally (comparatively to other PDEs) tertiary structure (and there are also minor modifications of the N-loop (788-811) ):<br \> | For each inhibitor, <scene name='60/604476/H_loop/1'>H-loop</scene> take a different and originally (comparatively to other PDEs) tertiary structure (and there are also minor modifications of the N-loop (788-811) ):<br \> | ||
* For an unliganded PDE5, <scene name='60/604476/H_loop/1'>H-loop</scene> take a coil conformation. [21]<br \> | * For an unliganded PDE5, <scene name='60/604476/H_loop/1'>H-loop</scene> take a coil conformation. [21]<br \> | ||
* In case of Sildenafil binding, a turn and an <scene name='60/604476/3-10helix/1'> | * In case of Sildenafil binding, a turn and an 3{{ind|10}}<scene name='60/604476/3-10helix/1'> helix (from 672 to 675)</scene> appear, and residues from 668 to 676 are disordered. The all loop cover the active site (by migrate of 24 Å from unliganded PDE5 loop structure, so the active site become a closed pocket). [21]<br \> | ||
* H-loop is less important in the interactions for Sildenafil and Icarisid II than cGMP.<br \> | * H-loop is less important in the interactions for Sildenafil and Icarisid II than cGMP.<br \> | ||