Sandbox Reserved 957: Difference between revisions

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 Binding amino acid for the Sildenafil:<br \>
-* R1 group have contacts with Gln817 (2 hydrogen bounds, so it increases Sildenafil affinity), Phe820 (Sildenafil stacks against it), Try612 (hydrogen bound so it increases Sildenafil affinity [24]), Leu765 and Ala767 [21]. And there is hydrophobic interactions between the pyrazol ring and residues Val782, Leu785, Tyr612 and Phe820 [24].<br \>
+* R1 group have contacts with <scene name='60/604476/R1-1/1'>Gln817</scene> (2 hydrogen bounds, so it increases Sildenafil affinity), <scene name='60/604476/R1-1/1'>Phe820</scene> (Sildenafil stacks against it), <scene name='60/604476/R1-1/1'>Try612</scene> (hydrogen bound so it increases Sildenafil affinity [24]), <scene name='60/604476/R1-1/1'>Leu765</scene> and <scene name='60/604476/R1-1/1'>Ala767</scene> [21]. And there is hydrophobic interactions between the pyrazol ring and residues <scene name='60/604476/R1-2/1'>Val782, Leu785, Tyr612 and Phe820</scene> [24].<br \>
 * R2 group is in the H pocket and has Van der Waals bounds with Val 782, Ala 783, Phe 786, Leu 804, Ile 813, Gln 817, Phe801. And interaction Pi-Pi between the phenyl ring and the Phe820.<br \>
 * R3 group is in the L pocket and has contacts with Asn 662, Ser 663, Tyr 664, Ile 665 (in the H-loop), Leu 804, Phe 801