Sandbox Reserved 958: Difference between revisions
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This process leads to an Imunnodeficiency that can indirectly undergo death by an opportunic infection. | This process leads to an Imunnodeficiency that can indirectly undergo death by an opportunic infection. | ||
== Structure == | == Structure == | ||
The HIV-1 integrase is a 288-amino acids length of 32 kDa expressed by the ''Pol'' gene. It leads to the synthesis of a polyprotein named Gag-Pol which will be cleaved by the HIV-protease and produced several proteins including integrase. | The HIV-1 integrase is a 288-amino acids length of 32 kDa expressed by the ''Pol'' gene. It leads to the synthesis of a '''polyprotein named Gag-Pol''' which will be cleaved by the HIV-protease and produced several proteins including integrase. | ||
This structure consists of two catalytic core domain monomers. Each monomer is composed of <scene name='60/604477/Sheets/1'>five beta sheets</scene> surrounded by <scene name='60/604477/Helix/1'>five alpha-helix</scene>. | This structure consists of two catalytic core domain monomers. Each monomer is composed of <scene name='60/604477/Sheets/1'>five beta sheets</scene> surrounded by <scene name='60/604477/Helix/1'>five alpha-helix</scene>. | ||
This protein is divided in three main domains: the N-terminal, the central and the C-terminal domain. | This protein is divided in three main domains: the N-terminal, the central and the C-terminal domain. | ||