2j0a: Difference between revisions
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[[Image:2j0a.jpg|left|200px]] | [[Image:2j0a.jpg|left|200px]] | ||
'''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE''' | {{Structure | ||
|PDB= 2j0a |SIZE=350|CAPTION= <scene name='initialview01'>2j0a</scene>, resolution 1.80Å | |||
|SITE= <scene name='pdbsite=AC1:K+Binding+Site+For+Chain+A'>AC1</scene> | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=K:POTASSIUM ION'>K</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/O-fucosylpeptide_3-beta-N-acetylglucosaminyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222] | |||
|GENE= | |||
}} | |||
'''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2J0A is a [ | 2J0A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0A OCA]. | ||
==Reference== | ==Reference== | ||
Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:[http:// | Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16964258 16964258] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]] | [[Category: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:35:49 2008'' | ||
Revision as of 18:35, 20 March 2008
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| , resolution 1.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | and | ||||||
| Activity: | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, with EC number 2.4.1.222 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE
OverviewOverview
Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify Notch receptors, altering their ligand-binding specificity to regulate Notch signaling in development. We present the crystal structure of mouse Manic Fringe bound to UDP and manganese. The structure reveals amino acid residues involved in recognition of donor substrates and catalysis, and a putative binding pocket for acceptor substrates. Mutations of several invariant residues in this pocket impair Fringe activity in vivo.
About this StructureAbout this Structure
2J0A is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258
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