2ar6: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ar6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AR6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ar6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AR6 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q8o|1q8o]], [[1n3o|1n3o]], [[1s1a|1s1a]], [[2arb|2arb]], [[2are|2are]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q8o|1q8o]], [[1n3o|1n3o]], [[1s1a|1s1a]], [[2arb|2arb]], [[2are|2are]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ar6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ar6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ar6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ar6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ar6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ar6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ar6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ar6 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Pterocarpus angolensis]] | [[Category: Pterocarpus angolensis]] | ||
[[Category: Amiot, N | [[Category: Amiot, N]] | ||
[[Category: Beeckmans, S | [[Category: Beeckmans, S]] | ||
[[Category: Boons, G J | [[Category: Boons, G J]] | ||
[[Category: Buts, L | [[Category: Buts, L]] | ||
[[Category: Garcia-Pino, A | [[Category: Garcia-Pino, A]] | ||
[[Category: Imberty, A | [[Category: Imberty, A]] | ||
[[Category: Loris, R | [[Category: Loris, R]] | ||
[[Category: Versees, W | [[Category: Versees, W]] | ||
[[Category: Wyns, L | [[Category: Wyns, L]] | ||
[[Category: Carbohydrate recognition]] | [[Category: Carbohydrate recognition]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 11:49, 8 January 2015
Pterocarpus angolensis Lectin (PAL) In Complex With The Pentasaccharide M592Pterocarpus angolensis Lectin (PAL) In Complex With The Pentasaccharide M592
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A. Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin.,Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R FEBS J. 2006 Jun;273(11):2407-20. PMID:16704415[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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