1vyt: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1vyt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYT FirstGlance]. <br> | <table><tr><td colspan='2'>[[1vyt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYT FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vyu|1vyu]], [[1vyv|1vyv]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vyu|1vyu]], [[1vyv|1vyv]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyt RCSB], [http://www.ebi.ac.uk/pdbsum/1vyt PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyt RCSB], [http://www.ebi.ac.uk/pdbsum/1vyt PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Chen, Y H | [[Category: Chen, Y H]] | ||
[[Category: Fitzmaurice, A | [[Category: Fitzmaurice, A]] | ||
[[Category: He, L L | [[Category: He, L L]] | ||
[[Category: Li, M H | [[Category: Li, M H]] | ||
[[Category: Tong, L | [[Category: Tong, L]] | ||
[[Category: Yamada, Y | [[Category: Yamada, Y]] | ||
[[Category: Yang, J | [[Category: Yang, J]] | ||
[[Category: Yang, S | [[Category: Yang, S]] | ||
[[Category: Zhang, H | [[Category: Zhang, H]] | ||
[[Category: Zhang, Y | [[Category: Zhang, Y]] | ||
[[Category: Aid doamin]] | [[Category: Aid doamin]] | ||
[[Category: Calcium channel beta subunit]] | [[Category: Calcium channel beta subunit]] | ||
Revision as of 16:42, 6 January 2015
BETA3 SUBUNIT COMPLEXED WITH AIDBETA3 SUBUNIT COMPLEXED WITH AID
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedHigh-voltage-activated Ca2+ channels are essential for diverse biological processes. They are composed of four or five subunits, including alpha1, alpha2-delta, beta and gamma (ref. 1). Their expression and function are critically dependent on the beta-subunit, which transports alpha1 to the surface membrane and regulates diverse channel properties. It is believed that the beta-subunit interacts with alpha1 primarily through the beta-interaction domain (BID), which binds directly to the alpha-interaction domain (AID) of alpha1; however, the molecular mechanism of the alpha1-beta interaction is largely unclear. Here we report the crystal structures of the conserved core region of beta3, alone and in complex with AID, and of beta4 alone. The structures show that the beta-subunit core contains two interacting domains: a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain. The AID binds to a hydrophobic groove in the GK domain through extensive interactions, conferring extremely high affinity between alpha1 and beta-subunits. The BID is essential both for the structural integrity of and for bridging the SH3 and GK domains, but it does not participate directly in binding alpha1. The presence of multiple protein-interacting modules in the beta-subunit opens a new dimension to its function as a multi-functional protein. Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels.,Chen YH, Li MH, Zhang Y, He LL, Yamada Y, Fitzmaurice A, Shen Y, Zhang H, Tong L, Yang J Nature. 2004 Jun 10;429(6992):675-80. Epub 2004 May 30. PMID:15170217[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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