1v87: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1v87]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V87 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V87 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1v87]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V87 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V87 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 2610524D08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 2610524D08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v87 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v87 RCSB], [http://www.ebi.ac.uk/pdbsum/1v87 PDBsum], [http://www.topsan.org/Proteins/RSGI/1v87 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v87 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v87 RCSB], [http://www.ebi.ac.uk/pdbsum/1v87 PDBsum], [http://www.topsan.org/Proteins/RSGI/1v87 TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE]] Recurrent site of retroviral integration in murine B-cell lymphomas. | [[http://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE]] Recurrent site of retroviral integration in murine B-cell lymphomas. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Inoue, M | [[Category: Inoue, M]] | ||
[[Category: Kigawa, T | [[Category: Kigawa, T]] | ||
[[Category: Koshiba, S | [[Category: Koshiba, S]] | ||
[[Category: Miyamoto, K | [[Category: Miyamoto, K]] | ||
[[Category: Muto, Y | [[Category: Muto, Y]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Tochio, N | [[Category: Tochio, N]] | ||
[[Category: Yokoyama, S | [[Category: Yokoyama, S]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Notch signaling]] | [[Category: Notch signaling]] | ||
[[Category: Ring-h2 domain]] | [[Category: Ring-h2 domain]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Zinc-binding domain]] | [[Category: Zinc-binding domain]] | ||
Revision as of 16:16, 6 January 2015
Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2
Structural highlights
Disease[DTX2_MOUSE] Recurrent site of retroviral integration in murine B-cell lymphomas. Function[DTX2_MOUSE] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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