1ujl: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ujl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJL FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ujl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujl RCSB], [http://www.ebi.ac.uk/pdbsum/1ujl PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujl RCSB], [http://www.ebi.ac.uk/pdbsum/1ujl PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Alewood, P F | [[Category: Alewood, P F]] | ||
[[Category: Bansal, P S | [[Category: Bansal, P S]] | ||
[[Category: Bauskin, A | [[Category: Bauskin, A]] | ||
[[Category: Breit, S N | [[Category: Breit, S N]] | ||
[[Category: Bursill, J A | [[Category: Bursill, J A]] | ||
[[Category: Campbell, T J | [[Category: Campbell, T J]] | ||
[[Category: Clarke, C E | [[Category: Clarke, C E]] | ||
[[Category: Kuchel, P W | [[Category: Kuchel, P W]] | ||
[[Category: Smith, D J | [[Category: Smith, D J]] | ||
[[Category: Sunde, M | [[Category: Sunde, M]] | ||
[[Category: Torres, A M | [[Category: Torres, A M]] | ||
[[Category: Vandenberg, J I | [[Category: Vandenberg, J I]] | ||
[[Category: Amphiphatic helix]] | [[Category: Amphiphatic helix]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Two helice]] | [[Category: Two helice]] | ||
Revision as of 15:40, 6 January 2015
Solution Structure of the HERG K+ channel S5-P extracellular linkerSolution Structure of the HERG K+ channel S5-P extracellular linker
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels. The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics.,Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:13680209[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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