1rzf: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1rzf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZF FirstGlance]. <br> | <table><tr><td colspan='2'>[[1rzf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZF FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rz7|1rz7]], [[1rz8|1rz8]], [[1rzg|1rzg]], [[1rzi|1rzi]], [[1rzj|1rzj]], [[1rzk|1rzk]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rz7|1rz7]], [[1rz8|1rz8]], [[1rzg|1rzg]], [[1rzi|1rzi]], [[1rzj|1rzj]], [[1rzk|1rzk]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rzf RCSB], [http://www.ebi.ac.uk/pdbsum/1rzf PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rzf RCSB], [http://www.ebi.ac.uk/pdbsum/1rzf PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Choe, H | [[Category: Choe, H]] | ||
[[Category: Dimitrov, D S | [[Category: Dimitrov, D S]] | ||
[[Category: Farzan, M | [[Category: Farzan, M]] | ||
[[Category: Hendrickson, W A | [[Category: Hendrickson, W A]] | ||
[[Category: Huang, C C | [[Category: Huang, C C]] | ||
[[Category: Kwong, P D | [[Category: Kwong, P D]] | ||
[[Category: Majeed, S | [[Category: Majeed, S]] | ||
[[Category: Moore, M J | [[Category: Moore, M J]] | ||
[[Category: Phogat, S | [[Category: Phogat, S]] | ||
[[Category: Robinson, J | [[Category: Robinson, J]] | ||
[[Category: Sodroski, J | [[Category: Sodroski, J]] | ||
[[Category: Venturi, M | [[Category: Venturi, M]] | ||
[[Category: Wyatt, R | [[Category: Wyatt, R]] | ||
[[Category: Zhang, M Y | [[Category: Zhang, M Y]] | ||
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Cd4i]] | [[Category: Cd4i]] | ||
Revision as of 11:04, 6 January 2015
Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition. Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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