2i6z: Difference between revisions

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[[Image:2i6z.jpg|left|200px]]<br /><applet load="2i6z" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2i6z.jpg|left|200px]]
caption="2i6z, resolution 1.90&Aring;" />
 
'''X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme'''<br />
{{Structure
|PDB= 2i6z |SIZE=350|CAPTION= <scene name='initialview01'>2i6z</scene>, resolution 1.90&Aring;
|SITE= <scene name='pdbsite=AC1:Cpt+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+A+500'>AC2</scene> and <scene name='pdbsite=AC3:Dms+Binding+Site+For+Residue+A+400'>AC3</scene>
|LIGAND= <scene name='pdbligand=CPT:CIS-PLATINUM-(NH3)2'>CPT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=DMS:DIMETHYL SULFOXIDE'>DMS</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]
|GENE=
}}
 
'''X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2I6Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CPT:'>CPT</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=DMS:'>DMS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Known structural/functional Sites: <scene name='pdbsite=AC1:Cpt+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+A+500'>AC2</scene> and <scene name='pdbsite=AC3:Dms+Binding+Site+For+Residue+A+400'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6Z OCA].  
2I6Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6Z OCA].  


==Reference==
==Reference==
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17180231 17180231]
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17180231 17180231]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
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[[Category: CPT]]
[[Category: CPT]]
[[Category: DMS]]
[[Category: DMS]]
[[Category: anticancer drugs]]
[[Category: anticancer drug]]
[[Category: cisplatin-lysozyme adduct]]
[[Category: cisplatin-lysozyme adduct]]
[[Category: hydrolase]]
[[Category: hydrolase]]


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