1s12: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1s12]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S12 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1s12]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S12 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s12 RCSB], [http://www.ebi.ac.uk/pdbsum/1s12 PDBsum], [http://www.topsan.org/Proteins/BSGC/1s12 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s12 RCSB], [http://www.ebi.ac.uk/pdbsum/1s12 PDBsum], [http://www.topsan.org/Proteins/BSGC/1s12 TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Jancarik, J | [[Category: Jancarik, J]] | ||
[[Category: Kim, R | [[Category: Kim, R]] | ||
[[Category: Kim, S H | [[Category: Kim, S H]] | ||
[[Category: Lou, Y | [[Category: Lou, Y]] | ||
[[Category: Shin, D H | [[Category: Shin, D H]] | ||
[[Category: Yokota, H | [[Category: Yokota, H]] | ||
[[Category: Bsgc]] | [[Category: Bsgc]] | ||
[[Category: Crystal]] | [[Category: Crystal]] | ||
[[Category: Hypothetical protein]] | [[Category: Hypothetical protein]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 09:52, 6 January 2015
Crystal structure of TM1457Crystal structure of TM1457
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystal structure of a hypothetical protein, TM1457, from Thermotoga maritima has been determined at 2.0A resolution. TM1457 belongs to the DUF464 family (57 members) for which there is no known function. The structure shows that it is composed of two helices in contact with one side of a five-stranded beta-sheet. Two identical monomers form a pseudo-dimer in the asymmetric unit. There is a large cleft between the first alpha-helix and the second beta-strand. This cleft may be functionally important, since the two highly conserved motifs, GHA and VCAXV(S/T), are located around the cleft. A structural comparison of TM1457 with known protein structures shows the best hit with another hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they share low structural similarity. Therefore, TM1457 still retains a unique topology and reveals a novel fold. Crystal structure of TM1457 from Thermotoga maritima.,Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:16242963[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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