2hts: Difference between revisions

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CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF THE HEAT SHOCK TRANSCRIPTION FACTOR

OverviewOverview

The structure of the DNA binding domain, determined at 1.8 angstrom resolution, contains a three-helix bundle that is capped by a four-stranded antiparallel beta sheet. This structure is a variant of the helix-turn-helix motif, typified by catabolite activator protein. In the heat shock transcription factor, the first helix of the motif (alpha 2) has an alpha-helical bulge and a proline-induced kink. The angle between the two helices of the motif (alpha 2 and alpha 3) is about 20 degrees smaller than the average for canonical helix-turn-helix proteins. Nevertheless, the relative positions of the first and third helices of the bundle (alpha 1 and alpha 3) are conserved. It is proposed here that the first helix of the three-helix bundle be considered a component of the helix-turn-helix motif.

About this StructureAbout this Structure

2HTS is a Single protein structure of sequence from Kluyveromyces lactis. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the DNA binding domain of the heat shock transcription factor., Harrison CJ, Bohm AA, Nelson HC, Science. 1994 Jan 14;263(5144):224-7. PMID:8284672

Page seeded by OCA on Thu Mar 20 17:21:28 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:2hts.gif|left|200px]]<br /><applet load="2hts" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2hts.gif|left|200px]]
-caption="2hts, resolution 1.83&Aring;" />
-'''CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF THE HEAT SHOCK TRANSCRIPTION FACTOR'''<br />
+ {{Structure
+|PDB= 2hts |SIZE=350|CAPTION= <scene name='initialview01'>2hts</scene>, resolution 1.83&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF THE HEAT SHOCK TRANSCRIPTION FACTOR'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-HTS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis] with <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTS OCA].
+HTS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTS OCA].
 ==Reference==
-Crystal structure of the DNA binding domain of the heat shock transcription factor., Harrison CJ, Bohm AA, Nelson HC, Science. 1994 Jan 14;263(5144):224-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8284672 8284672]
+Crystal structure of the DNA binding domain of the heat shock transcription factor., Harrison CJ, Bohm AA, Nelson HC, Science. 1994 Jan 14;263(5144):224-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8284672 8284672]
 [[Category: Kluyveromyces lactis]]
 [[Category: Single protein]]
@@ Line 18: / Line 27: @@
 [[Category: transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:21:28 2008''