1kgc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kgc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGC FirstGlance]. <br> | <table><tr><td colspan='2'>[[1kgc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KGC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgc RCSB], [http://www.ebi.ac.uk/pdbsum/1kgc PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kgc RCSB], [http://www.ebi.ac.uk/pdbsum/1kgc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Brooks, A G | [[Category: Brooks, A G]] | ||
[[Category: Clements, C S | [[Category: Clements, C S]] | ||
[[Category: Kjer-Nielsen, L | [[Category: Kjer-Nielsen, L]] | ||
[[Category: McCluskey, J | [[Category: McCluskey, J]] | ||
[[Category: Purcell, A W | [[Category: Purcell, A W]] | ||
[[Category: Rossjohn, J | [[Category: Rossjohn, J]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Lc13 clone]] | [[Category: Lc13 clone]] | ||
[[Category: T-cell receptor]] | [[Category: T-cell receptor]] | ||
Revision as of 18:19, 5 January 2015
Immune ReceptorImmune Receptor
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedDespite a potential repertoire of >10(15) alphabeta T cell receptors (TcR), the HLA B8-restricted cytolytic T cell response to a latent antigen of Epstein-Barr virus (EBV) is strikingly limited in the TcR sequences that are selected. Even in unrelated individuals this response is dominated by a single highly restricted TcR clonotype that selects identical combinations of hypervariable Valpha, Vbeta, D, J, and N region genes. We have determined the 1.5 A crystal structure of this "public" TcR, revealing that five of the six hypervariable loops adopt novel conformations providing a unique combining site that contains a deep pocket predicted to overlay the HLA B8-peptide complex. The findings suggest a structural basis for the immunodominance of this clonotype in the immune response to EBV. The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.,Kjer-Nielsen L, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J Structure. 2002 Nov;10(11):1521-32. PMID:12429093[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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