4c7j: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4c7j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C7J FirstGlance]. <br> | <table><tr><td colspan='2'>[[4c7j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C7J FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4YQ:4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5-CARBOXAMIDE'>4YQ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4YQ:4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5-CARBOXAMIDE'>4YQ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c7k|4c7k]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c7k|4c7k]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c7j RCSB], [http://www.ebi.ac.uk/pdbsum/4c7j PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c7j RCSB], [http://www.ebi.ac.uk/pdbsum/4c7j PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). | [[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). | ||
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</StructureSection> | </StructureSection> | ||
[[Category: 11-beta-hydroxysteroid dehydrogenase]] | [[Category: 11-beta-hydroxysteroid dehydrogenase]] | ||
[[Category: Boyd, S | [[Category: Boyd, S]] | ||
[[Category: Dossetter, A G | [[Category: Dossetter, A G]] | ||
[[Category: Goldberg, F W | [[Category: Goldberg, F W]] | ||
[[Category: Groombridge, S D | [[Category: Groombridge, S D]] | ||
[[Category: Gutierrez, P Morentin | [[Category: Gutierrez, P Morentin]] | ||
[[Category: Kemmitt, P D | [[Category: Kemmitt, P D]] | ||
[[Category: Robb, G R | [[Category: Robb, G R]] | ||
[[Category: Schoolmeester, J de | [[Category: Schoolmeester, J de]] | ||
[[Category: Scott, J S | [[Category: Scott, J S]] | ||
[[Category: Sjogren, T | [[Category: Sjogren, T]] | ||
[[Category: Swales, J G | [[Category: Swales, J G]] | ||
[[Category: Turnbull, A V | [[Category: Turnbull, A V]] | ||
[[Category: Wild, M J | [[Category: Wild, M J]] | ||
[[Category: Cns penetration]] | [[Category: Cns penetration]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Structure-based design]] | [[Category: Structure-based design]] | ||