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==Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase== | |||
<StructureSection load='4jlf' size='340' side='right' caption='[[4jlf]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4jlf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JLF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gdn|2gdn]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaA, blaC, Rv2068c, MT2128, MTCY49.07c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jlf RCSB], [http://www.ebi.ac.uk/pdbsum/4jlf PDBsum]</span></td></tr> | |||
</table> | |||
== | ==See Also== | ||
[[ | *[[Beta-lactamase|Beta-lactamase]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Blanchard, J | [[Category: Blanchard, J]] | ||
[[Category: Bonomo, R | [[Category: Bonomo, R]] | ||
[[Category: Hazra, S | [[Category: Hazra, S]] | ||
[[Category: Kurz, S | [[Category: Kurz, S]] | ||
[[Category: Beta-lactams inactivation]] | [[Category: Beta-lactams inactivation]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
Revision as of 17:09, 5 January 2015
Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamaseInhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase
Structural highlights
See Also |
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