4pp6: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pp6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PP6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4pp6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PP6 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=STL:RESVERATROL'>STL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ppp|4ppp]], [[4pps|4pps]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ppp|4ppp]], [[4pps|4pps]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pp6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pp6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pp6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pp6 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bruno, N E | [[Category: Bruno, N E]] | ||
[[Category: Cavett, V | [[Category: Cavett, V]] | ||
[[Category: Conkright, M D | [[Category: Conkright, M D]] | ||
[[Category: Garcia-Ordonez, R D | [[Category: Garcia-Ordonez, R D]] | ||
[[Category: Gjyshi, O | [[Category: Gjyshi, O]] | ||
[[Category: Griffin, P R | [[Category: Griffin, P R]] | ||
[[Category: Houtman, R | [[Category: Houtman, R]] | ||
[[Category: Hughes, T S | [[Category: Hughes, T S]] | ||
[[Category: Katzenellenbogen, J A | [[Category: Katzenellenbogen, J A]] | ||
[[Category: Kojetin, D J | [[Category: Kojetin, D J]] | ||
[[Category: Nettles, K W | [[Category: Nettles, K W]] | ||
[[Category: Nowak, J | [[Category: Nowak, J]] | ||
[[Category: Nwachukwu, J C | [[Category: Nwachukwu, J C]] | ||
[[Category: Parent, A A | [[Category: Parent, A A]] | ||
[[Category: Pollock, J A | [[Category: Pollock, J A]] | ||
[[Category: Srinivasan, S | [[Category: Srinivasan, S]] | ||
[[Category: Ligand binding]] | [[Category: Ligand binding]] | ||
[[Category: Nuclear hormone receptor]] | [[Category: Nuclear hormone receptor]] | ||