4ni2: Difference between revisions
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<StructureSection load='4ni2' size='340' side='right' caption='[[4ni2]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4ni2' size='340' side='right' caption='[[4ni2]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ni2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NI2 OCA]. <br> | <table><tr><td colspan='2'>[[4ni2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NI2 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GUC1A3, GUCSA3, GUCY1A1, GUCY1A3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GUC1B3, GUCSB3, GUCY1B1, GUCY1B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GUC1A3, GUCSA3, GUCY1A1, GUCY1A3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GUC1B3, GUCSB3, GUCY1B1, GUCY1B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ni2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ni2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ni2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ni2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ni2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ni2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ni2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ni2 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.,Seeger F, Quintyn R, Tanimoto A, Williams GJ, Tainer JA, Wysocki VH, Garcin ED Biochemistry. 2014 Apr 8;53(13):2153-65. doi: 10.1021/bi500129k. Epub 2014 Mar, 26. PMID:24669844<ref>PMID:24669844</ref> | Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.,Seeger F, Quintyn R, Tanimoto A, Williams GJ, Tainer JA, Wysocki VH, Garcin ED Biochemistry. 2014 Apr 8;53(13):2153-65. doi: 10.1021/bi500129k. Epub 2014 Mar, 26. PMID:24669844<ref>PMID:24669844</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Guanylate cyclase]] | [[Category: Guanylate cyclase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Garcin, E D | [[Category: Garcin, E D]] | ||
[[Category: Seeger, F | [[Category: Seeger, F]] | ||
[[Category: Tainer, J A | [[Category: Tainer, J A]] | ||
[[Category: Williams, G J | [[Category: Williams, G J]] | ||
[[Category: Cgmp biosynthesis]] | [[Category: Cgmp biosynthesis]] | ||
[[Category: Cyclase]] | [[Category: Cyclase]] | ||