4mvy: Difference between revisions

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<StructureSection load='4mvy' size='340' side='right' caption='[[4mvy]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
<StructureSection load='4mvy' size='340' side='right' caption='[[4mvy]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mvy]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3u1e 3u1e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVY OCA]. <br>
<table><tr><td colspan='2'>[[4mvy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3u1e 3u1e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVY FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=387:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-(3-HYDROXYPHENYL)UREA'>387</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene><br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=387:1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-(3-HYDROXYPHENYL)UREA'>387</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eg1|4eg1]], [[4eg3|4eg3]], [[4eg5|4eg5]], [[4mvw|4mvw]], [[4mvx|4mvx]], [[4mw0|4mw0]], [[4mw1|4mw1]], [[4mw2|4mw2]], [[4mw4|4mw4]], [[4mw5|4mw5]], [[4mw6|4mw6]], [[4mw7|4mw7]], [[4mw9|4mw9]], [[4mwb|4mwb]], [[4mwc|4mwc]], [[4mwd|4mwd]], [[4mwe|4mwe]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eg1|4eg1]], [[4eg3|4eg3]], [[4eg5|4eg5]], [[4mvw|4mvw]], [[4mvx|4mvx]], [[4mw0|4mw0]], [[4mw1|4mw1]], [[4mw2|4mw2]], [[4mw4|4mw4]], [[4mw5|4mw5]], [[4mw6|4mw6]], [[4mw7|4mw7]], [[4mw9|4mw9]], [[4mwb|4mwb]], [[4mwc|4mwc]], [[4mwd|4mwd]], [[4mwe|4mwe]]</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb10.70.6470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvy RCSB], [http://www.ebi.ac.uk/pdbsum/4mvy PDBsum]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvy RCSB], [http://www.ebi.ac.uk/pdbsum/4mvy PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.,Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775., eCollection 2014 Apr. PMID:24743796<ref>PMID:24743796</ref>
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.,Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775., eCollection 2014 Apr. PMID:24743796<ref>PMID:24743796</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Methionine--tRNA ligase]]
[[Category: Methionine--tRNA ligase]]
[[Category: Fan, E.]]
[[Category: Fan, E]]
[[Category: Hol, W G.J.]]
[[Category: Hol, W G.J]]
[[Category: Kim, J E.]]
[[Category: Kim, J E]]
[[Category: Koh, C Y.]]
[[Category: Koh, C Y]]
[[Category: Liu, J.]]
[[Category: Liu, J]]
[[Category: Schueren, W J.de van der.]]
[[Category: Schueren, W J.de van der]]
[[Category: Shibata, S.]]
[[Category: Shibata, S]]
[[Category: Verlinde, C L.M J.]]
[[Category: Verlinde, C L.M J]]
[[Category: Wetzel, A B.]]
[[Category: Wetzel, A B]]
[[Category: Zhang, Z.]]
[[Category: Zhang, Z]]
[[Category: Aar]]
[[Category: Aar]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Aminoacyl-trna synthetase]]

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