4dga: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4dga]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DGA FirstGlance]. <br> | <table><tr><td colspan='2'>[[4dga]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DGA FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dgb|4dgb]], [[4dgc|4dgc]], [[4dgd|4dgd]], [[4dge|4dge]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dgb|4dgb]], [[4dgc|4dgc]], [[4dgd|4dgd]], [[4dge|4dge]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIMCyp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 Macaca mulatta]), gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIMCyp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 Macaca mulatta]), gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dga RCSB], [http://www.ebi.ac.uk/pdbsum/4dga PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dga RCSB], [http://www.ebi.ac.uk/pdbsum/4dga PDBsum]</span></td></tr> | ||
<table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Diverse HIV viruses are targeted by a conformationally dynamic antiviral.,Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC Nat Struct Mol Biol. 2012 Mar 11. doi: 10.1038/nsmb.2253. PMID:22407016<ref>PMID:22407016</ref> | Diverse HIV viruses are targeted by a conformationally dynamic antiviral.,Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC Nat Struct Mol Biol. 2012 Mar 11. doi: 10.1038/nsmb.2253. PMID:22407016<ref>PMID:22407016</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| Line 26: | Line 26: | ||
[[Category: Macaca mulatta]] | [[Category: Macaca mulatta]] | ||
[[Category: Peptidylprolyl isomerase]] | [[Category: Peptidylprolyl isomerase]] | ||
[[Category: Bichel, K | [[Category: Bichel, K]] | ||
[[Category: Caines, M E.C | [[Category: Caines, M E.C]] | ||
[[Category: James, L C | [[Category: James, L C]] | ||
[[Category: McEwan, W A | [[Category: McEwan, W A]] | ||
[[Category: Price, A J | [[Category: Price, A J]] | ||
[[Category: Anti-viral protein]] | [[Category: Anti-viral protein]] | ||
[[Category: Isomerase-viral protein complex]] | [[Category: Isomerase-viral protein complex]] | ||
Revision as of 15:36, 4 January 2015
TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complexTRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex
Structural highlights
Publication Abstract from PubMedRhesus macaque TRIMCyp (RhTC) is a potent primate antiviral host protein that inhibits the replication of diverse HIV viruses. Here we show that it has acquired the ability to target multiple viruses by evolving an active site that interconverts between multiple conformations. Mutations that have relieved active site constraints allow RhTC to dynamically sample conformational space, including radically different conformers that target both HIV-1 and HIV-2 viruses. Introduction of a reversible constraint into RhTC allows specificity to be switched between a single conformation specific for HIV-1 and a dynamic ensemble that targets multiple viruses. These results show that conformational diversity can be used to expand the target diversity of innate immune receptors by supplementing their limited genetic variability with variability in protein structure. Diverse HIV viruses are targeted by a conformationally dynamic antiviral.,Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC Nat Struct Mol Biol. 2012 Mar 11. doi: 10.1038/nsmb.2253. PMID:22407016[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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