3zr7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3zr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR7 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c7a|2c7a]], [[2w8y|2w8y]], [[1e3k|1e3k]], [[3zra|3zra]], [[3zrb|3zrb]], [[1a28|1a28]], [[1zuc|1zuc]], [[1sqn|1sqn]], [[1sr7|1sr7]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c7a|2c7a]], [[2w8y|2w8y]], [[1e3k|1e3k]], [[3zra|3zra]], [[3zrb|3zrb]], [[1a28|1a28]], [[1zuc|1zuc]], [[1sqn|1sqn]], [[1sr7|1sr7]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zr7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zr7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr7 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Azevedo, R | [[Category: Azevedo, R]] | ||
[[Category: Brown, A R | [[Category: Brown, A R]] | ||
[[Category: Dechering, K | [[Category: Dechering, K]] | ||
[[Category: Hamilton, N M | [[Category: Hamilton, N M]] | ||
[[Category: Lam, T Wai | [[Category: Lam, T Wai]] | ||
[[Category: Lusher, S J | [[Category: Lusher, S J]] | ||
[[Category: Mcguire, R | [[Category: Mcguire, R]] | ||
[[Category: Nimz, O | [[Category: Nimz, O]] | ||
[[Category: Oubrie, A | [[Category: Oubrie, A]] | ||
[[Category: Raaijmakers, H C.A | [[Category: Raaijmakers, H C.A]] | ||
[[Category: Vlieg, J De | [[Category: Vlieg, J De]] | ||
[[Category: Vu-Pham, D | [[Category: Vu-Pham, D]] | ||
[[Category: Agonist]] | [[Category: Agonist]] | ||
[[Category: Antagonist]] | [[Category: Antagonist]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||