2giz: Difference between revisions
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[[Image:2giz.gif|left|200px]] | [[Image:2giz.gif|left|200px]] | ||
'''Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels''' | {{Structure | ||
|PDB= 2giz |SIZE=350|CAPTION= <scene name='initialview01'>2giz</scene>, resolution 1.68Å | |||
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'''Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2GIZ is a [ | 2GIZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. | ||
==Reference== | ==Reference== | ||
Structural and functional analysis of natrin, a venom protein that targets various ion channels., Wang F, Li H, Liu MN, Song H, Han HM, Wang QL, Yin CC, Zhou YC, Qi Z, Shu YY, Lin ZJ, Jiang T, Biochem Biophys Res Commun. 2006 Dec 15;351(2):443-8. Epub 2006 Oct 20. PMID:[http:// | Structural and functional analysis of natrin, a venom protein that targets various ion channels., Wang F, Li H, Liu MN, Song H, Han HM, Wang QL, Yin CC, Zhou YC, Qi Z, Shu YY, Lin ZJ, Jiang T, Biochem Biophys Res Commun. 2006 Dec 15;351(2):443-8. Epub 2006 Oct 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17070778 17070778] | ||
[[Category: Naja atra]] | [[Category: Naja atra]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: electrophysiology]] | [[Category: electrophysiology]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:05:14 2008'' | ||
Revision as of 18:05, 20 March 2008
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Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels
OverviewOverview
Cysteine-rich secretory proteins (CRISPs) are secreted single-chain proteins found in different sources. Natrin is a member of the CRISP family purified from the snake venom of Naja naja atra, which has been reported as a BKca channel blocker. In our study, crystals of natrin were obtained in two different crystal forms and the structure of one of them was solved at a resolution of 1.68A. Our electrophysiological experiments indicated that natrin can block the ion channel currents of the voltage-gated potassium channel Kv1.3. Docking analyses of the interaction between natrin and Kv1.3 revealed a novel interaction pattern different from the two previously reported K(+) channel inhibition models termed "functional dyad" and "basic ring". These findings offered new insights into the function of natrin and how the specific interactions between CRISPs and different ion channels can be achieved.
About this StructureAbout this Structure
2GIZ is a Single protein structure of sequence from Naja atra. Full crystallographic information is available from OCA.
ReferenceReference
Structural and functional analysis of natrin, a venom protein that targets various ion channels., Wang F, Li H, Liu MN, Song H, Han HM, Wang QL, Yin CC, Zhou YC, Qi Z, Shu YY, Lin ZJ, Jiang T, Biochem Biophys Res Commun. 2006 Dec 15;351(2):443-8. Epub 2006 Oct 20. PMID:17070778
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