3t6c: Difference between revisions

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[[Image:3t6c.png|left|200px]]
==Crystal structure of an enolase from pantoea ananatis (efi target efi-501676) with bound d-gluconate and mg==
 
<StructureSection load='3t6c' size='340' side='right' caption='[[3t6c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<!--
== Structural highlights ==
The line below this paragraph, containing "STRUCTURE_3t6c", creates the "Structure Box" on the page.
<table><tr><td colspan='2'>[[3t6c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pantoea_ananatis Pantoea ananatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T6C FirstGlance]. <br>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GCO:GLUCONIC+ACID'>GCO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rspA, PANA_0592 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=553 Pantoea ananatis])</td></tr>
or leave the SCENE parameter empty for the default display.
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t6c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t6c RCSB], [http://www.ebi.ac.uk/pdbsum/3t6c PDBsum]</span></td></tr>
-->
</table>
{{STRUCTURE_3t6c|  PDB=3t6c  |  SCENE=  }}
== Function ==
 
[[http://www.uniprot.org/uniprot/D4GJ14_PANAM D4GJ14_PANAM]] Has low D-gluconate dehydratase activity (in vitro), suggesting that it has no significant role in D-gluconate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro).<ref>PMID:24697546</ref> 
===Crystal structure of an enolase from pantoea ananatis (efi target efi-501676) with bound d-gluconate and mg===
== References ==
 
<references/>
 
__TOC__
==About this Structure==
</StructureSection>
[[3t6c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pantoea_ananatis Pantoea ananatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6C OCA].  
[[Category: Pantoea ananatis]]
[[Category: Pantoea ananatis]]
[[Category: Almo, S C.]]
[[Category: Almo, S C]]
[[Category: Bhosle, R.]]
[[Category: Bhosle, R]]
[[Category: Chowdhury, S.]]
[[Category: Chowdhury, S]]
[[Category: EFI, Enzyme Function Initiative.]]
[[Category: EFI, Enzyme Function Initiative]]
[[Category: Evans, B.]]
[[Category: Evans, B]]
[[Category: Gerlt, J A.]]
[[Category: Gerlt, J A]]
[[Category: Glenn, A Scott.]]
[[Category: Glenn, A Scott]]
[[Category: Hammonds, J.]]
[[Category: Hammonds, J]]
[[Category: Hillerich, B.]]
[[Category: Hillerich, B]]
[[Category: Imker, H J.]]
[[Category: Imker, H J]]
[[Category: Morisco, L L.]]
[[Category: Morisco, L L]]
[[Category: Toro, R.]]
[[Category: Toro, R]]
[[Category: Vetting, M W.]]
[[Category: Vetting, M W]]
[[Category: Washington, E.]]
[[Category: Washington, E]]
[[Category: Wasserman, S R.]]
[[Category: Wasserman, S R]]
[[Category: Zencheck, W D.]]
[[Category: Zencheck, W D]]
[[Category: Enolase]]
[[Category: Enolase]]
[[Category: Enzyme function intitiative]]
[[Category: Enzyme function intitiative]]

Revision as of 12:10, 4 January 2015

Crystal structure of an enolase from pantoea ananatis (efi target efi-501676) with bound d-gluconate and mgCrystal structure of an enolase from pantoea ananatis (efi target efi-501676) with bound d-gluconate and mg

Structural highlights

3t6c is a 2 chain structure with sequence from Pantoea ananatis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Gene:rspA, PANA_0592 (Pantoea ananatis)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[D4GJ14_PANAM] Has low D-gluconate dehydratase activity (in vitro), suggesting that it has no significant role in D-gluconate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro).[1]

References

  1. ↑ Wichelecki DJ, Balthazor BM, Chau AC, Vetting MW, Fedorov AA, Fedorov EV, Lukk T, Patskovsky YV, Stead MB, Hillerich BS, Seidel RD, Almo SC, Gerlt JA. Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup. Biochemistry. 2014 Apr 29;53(16):2722-31. doi: 10.1021/bi500264p. Epub 2014 Apr, 15. PMID:24697546 doi:http://dx.doi.org/10.1021/bi500264p

3t6c, resolution 1.60Å

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