2gc8: Difference between revisions

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-[[Image:2gc8.gif|left|200px]]<br /><applet load="2gc8" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2gc8.gif|left|200px]]
-caption="2gc8, resolution 2.20&Aring;" />
-'''Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase'''<br />
+ {{Structure
+|PDB= 2gc8 |SIZE=350|CAPTION= <scene name='initialview01'>2gc8</scene>, resolution 2.20&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=885:1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE'>885</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
+|GENE=
+}}
+'''Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-GC8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=885:'>885</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA].
+GC8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA].
 ==Reference==
-Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site., Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS, J Med Chem. 2006 Jun 1;49(11):3052-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16722622 16722622]
+Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site., Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS, J Med Chem. 2006 Jun 1;49(11):3052-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16722622 16722622]
 [[Category: Hepatitis c virus]]
 [[Category: RNA-directed RNA polymerase]]
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 [[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:30:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:02:57 2008''