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==YEAST INITIATOR TRNA== | |||
=== | <StructureSection load='1yfg' size='340' side='right' caption='[[1yfg]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1yfg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The March 2001 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Transfer RNA'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2001_3 10.2210/rcsb_pdb/mom_2001_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFG FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=1MG:1N-METHYLGUANOSINE-5-MONOPHOSPHATE'>1MG</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=M2G:N2-DIMETHYLGUANOSINE-5-MONOPHOSPHATE'>M2G</scene>, <scene name='pdbligand=RIA:2-O-[(5-PHOSPHO)RIBOSYL]ADENOSINE-5-MONOPHOSPHATE'>RIA</scene>, <scene name='pdbligand=T6A:N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5-MONOPHOSPHATE'>T6A</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yfg RCSB], [http://www.ebi.ac.uk/pdbsum/1yfg PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A significantly improved molecular model of yeast initiator tRNA (ytRNA(iMet) has been prepared that gives insight into the structural basis of eukaryotic initiator tRNA's unique function. This study was made possible by X-ray data collected at synchrotron radiation sources with the newly developed technologies of 'imaging plates' and 'storage phosphors'. These data extend beyond the resolution limit of 4.0 A reported previously to a current limit of 3.0 A and are considerably more accurate. Refinement of the model against the new data (R factor = 21.5%) clearly reveals a novel modification and a set of tertiary interactions involving sequence features characteristic of eukaryotic initiator tRNAs. We hypothesize these to be the structural elements responsible for part of the special function of yeast tRNA(iMET). | |||
The 3 A crystal structure of yeast initiator tRNA: functional implications in initiator/elongator discrimination.,Basavappa R, Sigler PB EMBO J. 1991 Oct;10(10):3105-11. PMID:1915284<ref>PMID:1915284</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Transfer RNA]] | [[Category: Transfer RNA]] | ||
[[Category: Basavappa, R | [[Category: Basavappa, R]] | ||
[[Category: Sigler, P B | [[Category: Sigler, P B]] | ||
[[Category: Amino acid transport]] | [[Category: Amino acid transport]] | ||
[[Category: T-rna]] | [[Category: T-rna]] | ||
[[Category: Transfer ribonucleic acid]] | [[Category: Transfer ribonucleic acid]] | ||
Revision as of 01:26, 4 January 2015
YEAST INITIATOR TRNAYEAST INITIATOR TRNA
Structural highlights
Publication Abstract from PubMedA significantly improved molecular model of yeast initiator tRNA (ytRNA(iMet) has been prepared that gives insight into the structural basis of eukaryotic initiator tRNA's unique function. This study was made possible by X-ray data collected at synchrotron radiation sources with the newly developed technologies of 'imaging plates' and 'storage phosphors'. These data extend beyond the resolution limit of 4.0 A reported previously to a current limit of 3.0 A and are considerably more accurate. Refinement of the model against the new data (R factor = 21.5%) clearly reveals a novel modification and a set of tertiary interactions involving sequence features characteristic of eukaryotic initiator tRNAs. We hypothesize these to be the structural elements responsible for part of the special function of yeast tRNA(iMET). The 3 A crystal structure of yeast initiator tRNA: functional implications in initiator/elongator discrimination.,Basavappa R, Sigler PB EMBO J. 1991 Oct;10(10):3105-11. PMID:1915284[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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