4rv8: Difference between revisions

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-'''Unreleased structure'''
+==Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131==
+<StructureSection load='4rv8' size='340' side='right' caption='[[4rv8]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-The entry 4rv8 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rv8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV8 FirstGlance]. <br>
-Authors: Kim, Y., Makowska-Grzyska, M., Gu, M., Kavitha, M., Hedstrom, L., Andesrson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=I13:1-(2-{3-[(1E)-N-(2-AMINOETHOXY)ETHANIMIDOYL]PHENYL}PROPAN-2-YL)-3-(4-CHLORO-3-NITROPHENYL)UREA'>I13</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-Description: Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ffs|3ffs]], [[4ixh|4ixh]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-[[Category: Makowska-Grzyska, M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv8 PDBsum]</span></td></tr>
-[[Category: Andesrson, W.F]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: IMP dehydrogenase]]
+[[Category: Andesrson, W F]]
+[[Category: Structural genomic]]
+[[Category: Gu, M]]
+[[Category: Hedstrom, L]]
+[[Category: Joachimiak, A]]
 [[Category: Kavitha, M]]
-[[Category: Joachimiak, A]]
-[[Category: Hedstrom, L]]
-[[Category: Gu, M]]
-[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
 [[Category: Kim, Y]]
+[[Category: Makowska-Grzyska, M]]
+[[Category: Alpha-beta fold]]
+[[Category: Csgid]]
+[[Category: National institute of allergy and infectious disease]]
+[[Category: Niaid]]
+[[Category: Oxidoreductase]]
+[[Category: Tim barrel]]