2fus: Difference between revisions

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[[Image:2fus.jpg|left|200px]]<br /><applet load="2fus" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fus.jpg|left|200px]]
caption="2fus, resolution 2.2&Aring;" />
 
'''MUTATIONS OF FUMARASE THAT DISTINGUISH BETWEEN THE ACTIVE SITE AND A NEARBY DICARBOXYLIC ACID BINDING SITE'''<br />
{{Structure
|PDB= 2fus |SIZE=350|CAPTION= <scene name='initialview01'>2fus</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=S1:The+Active+Site+Is+generat.+From+Three+Of+Four+Subunits+...'>S1</scene>
|LIGAND= <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2]
|GENE= FUMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''MUTATIONS OF FUMARASE THAT DISTINGUISH BETWEEN THE ACTIVE SITE AND A NEARBY DICARBOXYLIC ACID BINDING SITE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FUS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] Known structural/functional Site: <scene name='pdbsite=S1:The+Active+Site+Is+generat.+From+Three+Of+Four+Subunits+...'>S1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUS OCA].  
2FUS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUS OCA].  


==Reference==
==Reference==
Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site., Weaver T, Lees M, Banaszak L, Protein Sci. 1997 Apr;6(4):834-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9098893 9098893]
Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site., Weaver T, Lees M, Banaszak L, Protein Sci. 1997 Apr;6(4):834-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9098893 9098893]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Fumarate hydratase]]
[[Category: Fumarate hydratase]]
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[[Category: kreb's cycle enzyme]]
[[Category: kreb's cycle enzyme]]


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