Molecular Playground/ClpP: Difference between revisions
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<StructureSection load='1yg6' size='400' side='right' caption='E. coli ClpP protease' scene='60/609790/Clpp-2/2'> | <StructureSection load='1yg6' size='400' side='right' caption='E. coli ClpP protease (PDB code [[1yg6]].' scene='60/609790/Clpp-2/2'> | ||
== ClpP Introduction == | == ClpP Introduction == | ||
''E. coli'' Casein lytic proteinase P (ClpP) is a double ring [http://en.wiktionary.org/wiki/tetradecamer tetradecameric] homo oligomer compartmentalized peptidase [http://www.ncbi.nlm.nih.gov/pubmed/?term=ClpP%3A+A+structurally+dynamic+protease+regulated+by+AAA%2B+proteins]. ClpP requires the use of ATP dependent regulatory elements that independently bind to ClpP in order for substrates to have access the active core [http://www.ncbi.nlm.nih.gov/pubmed/15037252][http://www.ncbi.nlm.nih.gov/pubmed/20236930][http://www.ncbi.nlm.nih.gov/pubmed/19038348]. Here, proteins that are translocated by regulatory elements into the peptidase core are cleaved into smaller amino acid chains approximately on average 6-8aa in length [http://www.ncbi.nlm.nih.gov/pubmed/16229481]. | ''E. coli'' '''Casein lytic proteinase P (ClpP)''' is a double ring [http://en.wiktionary.org/wiki/tetradecamer tetradecameric] homo oligomer compartmentalized peptidase [http://www.ncbi.nlm.nih.gov/pubmed/?term=ClpP%3A+A+structurally+dynamic+protease+regulated+by+AAA%2B+proteins]. ClpP requires the use of ATP dependent regulatory elements that independently bind to ClpP in order for substrates to have access the active core [http://www.ncbi.nlm.nih.gov/pubmed/15037252][http://www.ncbi.nlm.nih.gov/pubmed/20236930][http://www.ncbi.nlm.nih.gov/pubmed/19038348]. Here, proteins that are translocated by regulatory elements into the peptidase core are cleaved into smaller amino acid chains approximately on average 6-8aa in length [http://www.ncbi.nlm.nih.gov/pubmed/16229481]. | ||
== Tetradecameric Structure == | == Tetradecameric Structure == | ||