4k5l: Difference between revisions

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-{{STRUCTURE_4k5l|  PDB=4k5l  |  SCENE=  }}
+==Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum==
-===Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum===
+<StructureSection load='4k5l' size='340' side='right' caption='[[4k5l]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
-{{ABSTRACT_PUBMED_23713488}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4k5l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_fcb1/columbia Plasmodium falciparum fcb1/columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K5L FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19N:[(1R)-1-AMINO-5-CARBAMIMIDAMIDOPENTYL]PHOSPHONIC+ACID'>19N</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k3n|4k3n]], [[4k5m|4k5m]], [[4k5n|4k5n]], [[4k5o|4k5o]], [[4k5p|4k5p]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k5l RCSB], [http://www.ebi.ac.uk/pdbsum/4k5l PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ]] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The malaria parasite &lt;i&gt;Plasmodium falciparum&lt;/i&gt; employs two metallo-aminopeptidases, P&lt;i&gt;f&lt;/i&gt;A-M1 and P&lt;I&gt;f&lt;/i&gt;A-M17, which are essential for parasite survival. Compounds that inhibit the activity of either enzyme represent leads for the development of new anti-malarial drugs. Here we report the synthesis and structure-activity-relationships of a small library of phosphonic acid arginine mimetics that probe the S1 pocket of both enzymes, and map the necessary interactions that would be important for a dual inhibitor.
-==Function==
+Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from &lt;i&gt;Plasmodium falciparum&lt;/i&gt;,Kannan Sivaraman K, Paiardini A, Sienczyk M, Ruggeri C, Oellig CA, Dalton JP, Scammells PJ, Drag M, McGowan S J Med Chem. 2013 May 28. PMID:23713488<ref>PMID:23713488</ref>
-[[http://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ]] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[4k5l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_fcb1/columbia Plasmodium falciparum fcb1/columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K5L OCA].
+</div>
-==Reference==
+==See Also==
-<ref group="xtra">PMID:023713488</ref><references group="xtra"/><references/>
+*[[Aminopeptidase|Aminopeptidase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Plasmodium falciparum fcb1/columbia]]
-[[Category: McGowan, S.]]
+[[Category: McGowan, S]]
 [[Category: Hydrolase-hydrolase inhibitor complex]]
 [[Category: M1 alanyl-aminopeptidase]]
 [[Category: Protease]]