3cwz: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [http://www.ebi.ac.uk/pdbsum/3cwz PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Goud, B | [[Category: Goud, B]] | ||
[[Category: Houdusse, A | [[Category: Houdusse, A]] | ||
[[Category: Khan, A R | [[Category: Khan, A R]] | ||
[[Category: Recacha, R | [[Category: Recacha, R]] | ||
[[Category: Er-golgi transport]] | [[Category: Er-golgi transport]] | ||
[[Category: Golgi]] | [[Category: Golgi]] | ||
Revision as of 01:26, 26 December 2014
Strucure of RAB6(GTP)-R6IP1 complexStrucure of RAB6(GTP)-R6IP1 complex
Structural highlights
Function[RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Publication Abstract from PubMedSmall GTPase Rab6 regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors. The crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 was solved at 3.2 angstroms resolution. This Rab6IP1 region encompasses an all alpha-helical RUN domain followed in tandem by a PLAT domain that adopts a beta sandwich fold. The structure reveals that the first and last alpha helices of the RUN domain mediate binding to switch I, switch II, and the interswitch region of Rab6. It represents the largest Rab-effector complex determined to date. Comparisons with the recent structure of Rab6 in complex with an unrelated effector, human golgin GCC185, reveals significant conformational changes in the conserved hydrophobic triad of Rab6. Flexibility in the switch and interswitch regions of Rab6 mediates recognition of compositionally distinct alpha-helical coiled coils, thereby contributing to Rab6 promiscuity in effector recruitment. Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain.,Recacha R, Boulet A, Jollivet F, Monier S, Houdusse A, Goud B, Khan AR Structure. 2009 Jan 14;17(1):21-30. PMID:19141279[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Homo sapiens
- Mus musculus
- Goud, B
- Houdusse, A
- Khan, A R
- Recacha, R
- Er-golgi transport
- Golgi
- Golgi apparatus
- Gtp-binding
- Guanosine 5' triphosphate
- Lipase
- Lipoprotein
- Lipoxygenase
- Membrane
- Methylation
- Nesca plat
- Nucleotide-binding
- Phosphoprotein
- Prenylation
- Protein transport
- Rab small gtpase
- Rab-binding domain
- Rab6 interacting protein 1
- Rpip8
- Run
- Transport
- Transport protein
- Unc-14