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==Crystal Structure of DR_1245 from Deinococcus radiodurans== | |||
=== | <StructureSection load='4h5b' size='340' side='right' caption='[[4h5b]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4h5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H5B FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DR_1245 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 Deinococcus radiodurans R1])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h5b RCSB], [http://www.ebi.ac.uk/pdbsum/4h5b PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates. | |||
The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones.,Norais C, Servant P, Bouthier-de-la-Tour C, Coureux PD, Ithurbide S, Vannier F, Guerin PP, Dulberger CL, Satyshur KA, Keck JL, Armengaud J, Cox MM, Sommer S PLoS One. 2013;8(2):e56558. doi: 10.1371/journal.pone.0056558. Epub 2013 Feb 18. PMID:23441204<ref>PMID:23441204</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Deinococcus radiodurans r1]] | [[Category: Deinococcus radiodurans r1]] | ||
[[Category: Armengaud, J | [[Category: Armengaud, J]] | ||
[[Category: Bouthier-de-la-Tour, C | [[Category: Bouthier-de-la-Tour, C]] | ||
[[Category: Coureux, P D | [[Category: Coureux, P D]] | ||
[[Category: Cox, M M | [[Category: Cox, M M]] | ||
[[Category: Dulberger, C L | [[Category: Dulberger, C L]] | ||
[[Category: Guerin, P | [[Category: Guerin, P]] | ||
[[Category: Ithurbide, S | [[Category: Ithurbide, S]] | ||
[[Category: Keck, J L | [[Category: Keck, J L]] | ||
[[Category: Norais, C | [[Category: Norais, C]] | ||
[[Category: Satyshur, K A | [[Category: Satyshur, K A]] | ||
[[Category: Servant, P | [[Category: Servant, P]] | ||
[[Category: Sommer, S | [[Category: Sommer, S]] | ||
[[Category: Vannier, F | [[Category: Vannier, F]] | ||
[[Category: Secretion chaperone-like fold]] | [[Category: Secretion chaperone-like fold]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 01:09, 26 December 2014
Crystal Structure of DR_1245 from Deinococcus radioduransCrystal Structure of DR_1245 from Deinococcus radiodurans
Structural highlights
Publication Abstract from PubMedThe bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates. The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones.,Norais C, Servant P, Bouthier-de-la-Tour C, Coureux PD, Ithurbide S, Vannier F, Guerin PP, Dulberger CL, Satyshur KA, Keck JL, Armengaud J, Cox MM, Sommer S PLoS One. 2013;8(2):e56558. doi: 10.1371/journal.pone.0056558. Epub 2013 Feb 18. PMID:23441204[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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