2vrr: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vrr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VRR FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vrr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VRR FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a5r|1a5r]], [[2asq|2asq]], [[2uyz|2uyz]], [[2bf8|2bf8]], [[1u9a|1u9a]], [[2iy1|2iy1]], [[1tgz|1tgz]], [[1z5s|1z5s]], [[2iy0|2iy0]], [[1wyw|1wyw]], [[1u9b|1u9b]], [[2io2|2io2]], [[1y8r|1y8r]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a5r|1a5r]], [[2asq|2asq]], [[2uyz|2uyz]], [[2bf8|2bf8]], [[1u9a|1u9a]], [[2iy1|2iy1]], [[1tgz|1tgz]], [[1z5s|1z5s]], [[2iy0|2iy0]], [[1wyw|1wyw]], [[1u9b|1u9b]], [[2io2|2io2]], [[1y8r|1y8r]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vrr RCSB], [http://www.ebi.ac.uk/pdbsum/2vrr PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vrr RCSB], [http://www.ebi.ac.uk/pdbsum/2vrr PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/UBC9_MOUSE UBC9_MOUSE]] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).<ref>PMID:16326389</ref> <ref>PMID:17187077</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Ubiquitin--protein ligase]] | [[Category: Ubiquitin--protein ligase]] | ||
[[Category: Dijk, W J.Van | [[Category: Dijk, W J.Van]] | ||
[[Category: Fish, A | [[Category: Fish, A]] | ||
[[Category: Flotho, A | [[Category: Flotho, A]] | ||
[[Category: Johnson, E S | [[Category: Johnson, E S]] | ||
[[Category: Klug, H | [[Category: Klug, H]] | ||
[[Category: Knipscheer, P | [[Category: Knipscheer, P]] | ||
[[Category: Mann, M | [[Category: Mann, M]] | ||
[[Category: Olsen, J V | [[Category: Olsen, J V]] | ||
[[Category: Pichler, A | [[Category: Pichler, A]] | ||
[[Category: Sixma, T K | [[Category: Sixma, T K]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cell cycle-ligase complex]] | [[Category: Cell cycle-ligase complex]] | ||