4oar: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oar OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oar RCSB], [http://www.ebi.ac.uk/pdbsum/4oar PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oar OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oar RCSB], [http://www.ebi.ac.uk/pdbsum/4oar PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Fagart, J | [[Category: Fagart, J]] | ||
[[Category: Fay, M R | [[Category: Fay, M R]] | ||
[[Category: Gainer, E | [[Category: Gainer, E]] | ||
[[Category: Petit-Topin, I | [[Category: Petit-Topin, I]] | ||
[[Category: Rafestin-Oblin, M E | [[Category: Rafestin-Oblin, M E]] | ||
[[Category: Resche-Rigon, M | [[Category: Resche-Rigon, M]] | ||
[[Category: Ulmann, A | [[Category: Ulmann, A]] | ||
[[Category: Contraception]] | [[Category: Contraception]] | ||
[[Category: Nuclear receptor]] | [[Category: Nuclear receptor]] | ||