4b9d: Difference between revisions

Revision as of 23:23, 25 December 2014

Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.

Structural highlights

4b9d is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	4apc
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:	FirstGlance, OCA, RCSB, PDBsum

Disease

[NEK1_HUMAN] Short rib-polydactyly syndrome, Majewski type. The disease is caused by mutations affecting the gene represented in this entry. In some cases NEK1 mutations result in disease phenotype in the presence of mutations in DYNC2H1 indicating digenic inheritance (digenic short rib-polydactyly syndrome 3/6 with polydactyly) (PubMed:21211617).^[1]

Function

[NEK1_HUMAN] Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.^[2] ^[3]

References

↑ Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB, Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH, Rauch A. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet. 2011 Jan 7;88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004. PMID:21211617 doi:http://dx.doi.org/10.1016/j.ajhg.2010.12.004
↑ Chen Y, Gaczynska M, Osmulski P, Polci R, Riley DJ. Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1. Biochem Biophys Res Commun. 2010 Apr 9;394(3):798-803. doi:, 10.1016/j.bbrc.2010.03.077. Epub 2010 Mar 15. PMID:20230784 doi:http://dx.doi.org/10.1016/j.bbrc.2010.03.077
↑ Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB, Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH, Rauch A. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet. 2011 Jan 7;88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004. PMID:21211617 doi:http://dx.doi.org/10.1016/j.ajhg.2010.12.004

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OCA

[1] Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB, Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH, Rauch A. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet. 2011 Jan 7;88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004. PMID:21211617 doi:http://dx.doi.org/10.1016/j.ajhg.2010.12.004

[2] Chen Y, Gaczynska M, Osmulski P, Polci R, Riley DJ. Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1. Biochem Biophys Res Commun. 2010 Apr 9;394(3):798-803. doi:, 10.1016/j.bbrc.2010.03.077. Epub 2010 Mar 15. PMID:20230784 doi:http://dx.doi.org/10.1016/j.bbrc.2010.03.077

[3] Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB, Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH, Rauch A. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet. 2011 Jan 7;88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004. PMID:21211617 doi:http://dx.doi.org/10.1016/j.ajhg.2010.12.004

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-[[Image:4b9d.jpg|left|200px]]
+==Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.==
+<StructureSection load='4b9d' size='340' side='right' caption='[[4b9d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4b9d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9D FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CK7:[4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE'>CK7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4apc|4apc]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b9d RCSB], [http://www.ebi.ac.uk/pdbsum/4b9d PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/NEK1_HUMAN NEK1_HUMAN]] Short rib-polydactyly syndrome, Majewski type. The disease is caused by mutations affecting the gene represented in this entry. In some cases NEK1 mutations result in disease phenotype in the presence of mutations in DYNC2H1 indicating digenic inheritance (digenic short rib-polydactyly syndrome 3/6 with polydactyly) (PubMed:21211617).<ref>PMID:21211617</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/NEK1_HUMAN NEK1_HUMAN]] Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.<ref>PMID:20230784</ref> <ref>PMID:21211617</ref>
-{{STRUCTURE_4b9d|  PDB=4b9d  |  SCENE=  }}
+==See Also==
+*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
-===Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.===
+== References ==
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4b9d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9D OCA].
 [[Category: Homo sapiens]]
 [[Category: Non-specific serine/threonine protein kinase]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith, C]]
-[[Category: Basei, F L.]]
+[[Category: Basei, F L]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Canning, P.]]
+[[Category: Canning, P]]
-[[Category: Delft, F Von.]]
+[[Category: Delft, F Von]]
-[[Category: Edwards, A.]]
+[[Category: Edwards, A]]
-[[Category: Elkins, J M.]]
+[[Category: Elkins, J M]]
-[[Category: Hanchuk, T D.M.]]
+[[Category: Hanchuk, T D.M]]
-[[Category: Knapp, S.]]
+[[Category: Knapp, S]]
-[[Category: Kobarg, J.]]
+[[Category: Kobarg, J]]
-[[Category: Krojer, T.]]
+[[Category: Krojer, T]]
-[[Category: Lovato, D V.]]
+[[Category: Lovato, D V]]
-[[Category: Mahajan, P.]]
+[[Category: Mahajan, P]]
-[[Category: Meirelles, G V.]]
+[[Category: Meirelles, G V]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike, A C.W]]
-[[Category: Raynor, J.]]
+[[Category: Raynor, J]]
-[[Category: Rellos, P.]]
+[[Category: Rellos, P]]
-[[Category: Szklarz, M.]]
+[[Category: Szklarz, M]]
-[[Category: Vollmar, M.]]
+[[Category: Vollmar, M]]
-[[Category: Zhang, Y.]]
+[[Category: Zhang, Y]]
 [[Category: Inhibitor]]
 [[Category: Transferase]]

4b9d: Difference between revisions

Revision as of 23:23, 25 December 2014

Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.

Structural highlights

Disease

Function

See Also

References

Contents

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4b9d: Difference between revisions

Revision as of 23:23, 25 December 2014

Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.

Structural highlights

Disease

Function

See Also

References

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Navigation menu

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