2f3k: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:
[[Image:2f3k.jpg|left|200px]]<br /><applet load="2f3k" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2f3k.jpg|left|200px]]
caption="2f3k, resolution 1.599&Aring;" />
 
'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''<br />
{{Structure
|PDB= 2f3k |SIZE=350|CAPTION= <scene name='initialview01'>2f3k</scene>, resolution 1.599&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=RO1:(3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE'>RO1</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
2F3K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=RO1:'>RO1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3K OCA].  
2F3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3K OCA].  


==Reference==
==Reference==
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16569872 16569872]
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16569872 16569872]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
Line 27: Line 36:
[[Category: substrate envelope]]
[[Category: substrate envelope]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:17:23 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:47:38 2008''

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA