2b05: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2b05]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B05 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2b05]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B05 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YWHAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YWHAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b05 RCSB], [http://www.ebi.ac.uk/pdbsum/2b05 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b05 RCSB], [http://www.ebi.ac.uk/pdbsum/2b05 PDBsum]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/1433G_HUMAN 1433G_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:16511572</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[14-3-3 protein|14-3-3 protein]]
*[[14-3-3 protein|14-3-3 protein]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith, C]]
[[Category: Debreczeni, E J.]]
[[Category: Debreczeni, E J]]
[[Category: Delft, F von.]]
[[Category: Delft, F von]]
[[Category: Doyle, D.]]
[[Category: Doyle, D]]
[[Category: Edwards, A.]]
[[Category: Edwards, A]]
[[Category: Elkins, J.]]
[[Category: Elkins, J]]
[[Category: Papagrigoriou, E.]]
[[Category: Papagrigoriou, E]]
[[Category: Turnbull, A.]]
[[Category: Turnbull, A]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Yang, X.]]
[[Category: Yang, X]]
[[Category: Zhao, Y.]]
[[Category: Zhao, Y]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]

Revision as of 22:46, 25 December 2014

Crystal Structure of 14-3-3 gamma in complex with a phosphoserine peptideCrystal Structure of 14-3-3 gamma in complex with a phosphoserine peptide

Structural highlights

2b05 is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Gene:YWHAG (Homo sapiens)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[1433G_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 Mar 22;25(6):1207-18. Epub 2006 Mar 2. PMID:16511572 doi:10.1038/sj.emboj.7601010

2b05, resolution 2.55Å

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