3uux: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3uux]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UUX FirstGlance]. <br> | <table><tr><td colspan='2'>[[3uux]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UUX FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pqn|2pqn]], [[2pqr|2pqr]], [[2xu6|2xu6]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pqn|2pqn]], [[2pqr|2pqr]], [[2xu6|2xu6]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FIS1, MDV2, YIL065C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), MDV1, FIS2, GAG3, NET2, YJL112W, J0802 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FIS1, MDV2, YIL065C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c]), MDV1, FIS2, GAG3, NET2, YJL112W, J0802 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uux OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uux RCSB], [http://www.ebi.ac.uk/pdbsum/3uux PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uux OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uux RCSB], [http://www.ebi.ac.uk/pdbsum/3uux PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/FIS1_YEAST FIS1_YEAST]] Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation. Required for targeting MDV1 to the mitochondria. Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division.<ref>PMID:11038183</ref> <ref>PMID:11038182</ref> <ref>PMID:12163467</ref> <ref>PMID:12679388</ref> [[http://www.uniprot.org/uniprot/MDV1_YEAST MDV1_YEAST]] Involved in mitochondrial fission. Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.<ref>PMID:11038182</ref> <ref>PMID:11038180</ref> <ref>PMID:11038183</ref> <ref>PMID:12163467</ref> <ref>PMID:16247028</ref> <ref>PMID:16272155</ref> <ref>PMID:16601120</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (mdv1) coiled coil.,Zhang Y, Chan NC, Ngo HB, Gristick H, Chan DC J Biol Chem. 2012 Mar 23;287(13):9855-61. Epub 2012 Feb 1. PMID:22303011<ref>PMID:22303011</ref> | Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (mdv1) coiled coil.,Zhang Y, Chan NC, Ngo HB, Gristick H, Chan DC J Biol Chem. 2012 Mar 23;287(13):9855-61. Epub 2012 Feb 1. PMID:22303011<ref>PMID:22303011</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae s288c]] | [[Category: Saccharomyces cerevisiae s288c]] | ||
[[Category: Chan, D C | [[Category: Chan, D C]] | ||
[[Category: Chan, N C | [[Category: Chan, N C]] | ||
[[Category: Gristick, H | [[Category: Gristick, H]] | ||
[[Category: Zhang, Y | [[Category: Zhang, Y]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Mitochondria and cytoplasm]] | [[Category: Mitochondria and cytoplasm]] | ||
[[Category: Mitochondrial fission]] | [[Category: Mitochondrial fission]] | ||
[[Category: Tetratricopeptide repeat]] | [[Category: Tetratricopeptide repeat]] | ||