2eva: Difference between revisions
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[[Image:2eva.gif|left|200px]] | [[Image:2eva.gif|left|200px]] | ||
'''Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1''' | {{Structure | ||
|PDB= 2eva |SIZE=350|CAPTION= <scene name='initialview01'>2eva</scene>, resolution 2.0Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ADN:ADENOSINE'>ADN</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | |||
|GENE= MAP3K7, TAK1/MAP3K7IP1, TAB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2EVA is a [ | 2EVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVA OCA]. | ||
==Reference== | ==Reference== | ||
Structural basis for the interaction of TAK1 kinase with its activating protein TAB1., Brown K, Vial SC, Dedi N, Long JM, Dunster NJ, Cheetham GM, J Mol Biol. 2005 Dec 16;354(5):1013-20. Epub 2005 Nov 2. PMID:[http:// | Structural basis for the interaction of TAK1 kinase with its activating protein TAB1., Brown K, Vial SC, Dedi N, Long JM, Dunster NJ, Cheetham GM, J Mol Biol. 2005 Dec 16;354(5):1013-20. Epub 2005 Nov 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16289117 16289117] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: tak1]] | [[Category: tak1]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:44:47 2008'' | ||
Revision as of 17:44, 20 March 2008
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| , resolution 2.0Å | |||||||
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| Ligands: | |||||||
| Gene: | MAP3K7, TAK1/MAP3K7IP1, TAB1 (Homo sapiens) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1
OverviewOverview
Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a member of the MAPKKK family of protein kinases, and is involved in intracellular signalling pathways stimulated by transforming growth factor beta, interleukin-1 and tumour necrosis factor-alpha. TAK1 is known to rely upon an additional protein, TAK1-binding protein 1 (TAB1), for complete activation. However, the molecular basis for this activation has yet to be elucidated. We have solved the crystal structure of a novel TAK1 chimeric protein and these data give insight into how TAK1 is activated by TAB1. Our results reveal a novel binding pocket on the TAK1 kinase domain whose shape complements that of a unique alpha-helix in the TAK1 binding domain of TAB1, providing the basis for an intimate hydrophobic association between the protein activator and its target.
About this StructureAbout this Structure
2EVA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for the interaction of TAK1 kinase with its activating protein TAB1., Brown K, Vial SC, Dedi N, Long JM, Dunster NJ, Cheetham GM, J Mol Biol. 2005 Dec 16;354(5):1013-20. Epub 2005 Nov 2. PMID:16289117
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