Structural genomics: Difference between revisions
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Structural genomics is a large, international project, started around 2001, that aims to determine new protein structures using high throughput techniques, and to develop faster techniques for [[X-ray crystallography]] and [[NMR]]. | Structural genomics is a large, international project, started around 2001, that aims to determine new protein structures using high throughput techniques, and to develop faster techniques for [[X-ray crystallography]] and [[NMR]]. | ||
Protein sequences are often selected for structure determination because they represent a sequence-family for which no member's structure is known. These are called ''target sequences''. Determination of the structure of such a sequence enables the structures of other sequence-related proteins to be predicted by [[homology modeling]]. Many of the institutions participating in structural genomics report their target sequences, and their progress in determining their structures, in | Protein sequences are often selected for structure determination because they represent a sequence-family for which no member's structure is known. These are called ''target sequences''. Determination of the structure of such a sequence enables the structures of other sequence-related proteins to be predicted by [[homology modeling]]. Many of the institutions participating in structural genomics report their target sequences, and their progress in determining their structures, in [http://sbkb.org/tt/ TargetTrack, the Structural Biology Target Registration Database]. | ||
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