3e6t: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3e6t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E6T FirstGlance]. <br> | <table><tr><td colspan='2'>[[3e6t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E6T FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1A2:5-(4-AMINO-1-ETHYL-5,8-DIFLUORO-1H-SPIRO[PIPERIDINE-4,2-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE'>1A2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1A2:5-(4-AMINO-1-ETHYL-5,8-DIFLUORO-1H-SPIRO[PIPERIDINE-4,2-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE'>1A2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e65|3e65]], [[3e67|3e67]], [[3e68|3e68]], [[3e6l|3e6l]], [[3e6n|3e6n]], [[3e6o|3e6o]], [[3e7g|3e7g]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e65|3e65]], [[3e67|3e67]], [[3e68|3e68]], [[3e6l|3e6l]], [[3e6n|3e6n]], [[3e6o|3e6o]], [[3e7g|3e7g]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e6t RCSB], [http://www.ebi.ac.uk/pdbsum/3e6t PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e6t RCSB], [http://www.ebi.ac.uk/pdbsum/3e6t PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 35: | Line 37: | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Nitric-oxide synthase]] | [[Category: Nitric-oxide synthase]] | ||
[[Category: Aberg, A | [[Category: Aberg, A]] | ||
[[Category: Andersson, G | [[Category: Andersson, G]] | ||
[[Category: Andrews, G | [[Category: Andrews, G]] | ||
[[Category: Arvai, A S | [[Category: Arvai, A S]] | ||
[[Category: Cheshire, D R | [[Category: Cheshire, D R]] | ||
[[Category: Connolly, S | [[Category: Connolly, S]] | ||
[[Category: Crane, B R | [[Category: Crane, B R]] | ||
[[Category: Garcin, E D | [[Category: Garcin, E D]] | ||
[[Category: Gensmantel, N P | [[Category: Gensmantel, N P]] | ||
[[Category: Getzoff, E D | [[Category: Getzoff, E D]] | ||
[[Category: Hamley, P J | [[Category: Hamley, P J]] | ||
[[Category: Kroeger, M D | [[Category: Kroeger, M D]] | ||
[[Category: Mallinder, P R | [[Category: Mallinder, P R]] | ||
[[Category: Mete, A | [[Category: Mete, A]] | ||
[[Category: Nicholls, D J | [[Category: Nicholls, D J]] | ||
[[Category: Rosenfeld, R J | [[Category: Rosenfeld, R J]] | ||
[[Category: St-Gallay, S A | [[Category: St-Gallay, S A]] | ||
[[Category: Stueh, D J | [[Category: Stueh, D J]] | ||
[[Category: Tainer, J A | [[Category: Tainer, J A]] | ||
[[Category: Tinker, A C | [[Category: Tinker, A C]] | ||
[[Category: Wallace, A V | [[Category: Wallace, A V]] | ||
[[Category: Calmodulin-binding]] | [[Category: Calmodulin-binding]] | ||
[[Category: Fad]] | [[Category: Fad]] | ||