4mrz: Difference between revisions
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<StructureSection load='4mrz' size='340' side='right' caption='[[4mrz]], [[Resolution|resolution]] 1.58Å' scene=''> | <StructureSection load='4mrz' size='340' side='right' caption='[[4mrz]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mrz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRZ OCA]. <br> | <table><tr><td colspan='2'>[[4mrz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRZ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ZV:4-METHYL-3-NITROPYRIDIN-2-AMINE'>2ZV</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ZV:4-METHYL-3-NITROPYRIDIN-2-AMINE'>2ZV</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrw|4mrw]], [[4ms0|4ms0]], [[4msa|4msa]], [[4msc|4msc]], [[4mse|4mse]], [[4msh|4msh]], [[4msn|4msn]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrw|4mrw]], [[4ms0|4ms0]], [[4msa|4msa]], [[4msc|4msc]], [[4mse|4mse]], [[4msh|4msh]], [[4msn|4msn]]</td></tr> | ||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mrz RCSB], [http://www.ebi.ac.uk/pdbsum/4mrz PDBsum]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.,Recht MI, Sridhar V, Badger J, Bounaud PY, Logan C, Chie-Leon B, Nienaber V, Torres FE J Biomol Screen. 2013 Dec 27. PMID:24375910<ref>PMID:24375910</ref> | Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.,Recht MI, Sridhar V, Badger J, Bounaud PY, Logan C, Chie-Leon B, Nienaber V, Torres FE J Biomol Screen. 2013 Dec 27. PMID:24375910<ref>PMID:24375910</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Badger, J | [[Category: Badger, J]] | ||
[[Category: Chie-Leon, B | [[Category: Chie-Leon, B]] | ||
[[Category: Logan, C | [[Category: Logan, C]] | ||
[[Category: Nienaber, V | [[Category: Nienaber, V]] | ||
[[Category: Sridhar, V | [[Category: Sridhar, V]] | ||
[[Category: Fragment screening]] | [[Category: Fragment screening]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||