3mr1: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mr1 RCSB], [http://www.ebi.ac.uk/pdbsum/3mr1 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mr1 RCSB], [http://www.ebi.ac.uk/pdbsum/3mr1 PDBsum]</span></td></tr>
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== Function ==
[[http://www.uniprot.org/uniprot/AMPM_RICPR AMPM_RICPR]] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 20:03, 25 December 2014

Crystal structure of methionine aminopeptidase from Rickettsia prowazekiiCrystal structure of methionine aminopeptidase from Rickettsia prowazekii

Structural highlights

3mr1 is a 4 chain structure with sequence from Rickettsia prowazekii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Gene:map, Q9ZCD3, RP824 (Rickettsia prowazekii)
Activity:Methionyl aminopeptidase, with EC number 3.4.11.18
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[AMPM_RICPR] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3mr1, resolution 2.00Å

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