2xx5: Difference between revisions
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<StructureSection load='2xx5' size='340' side='right' caption='[[2xx5]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2xx5' size='340' side='right' caption='[[2xx5]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xx5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XX5 OCA]. <br> | <table><tr><td colspan='2'>[[2xx5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XX5 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13N:(5E,10R)-N-BENZYL-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDRO-2-BENZAZACYCLOTETRADECINE-10-CARBOXAMIDE'>13N</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13N:(5E,10R)-N-BENZYL-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDRO-2-BENZAZACYCLOTETRADECINE-10-CARBOXAMIDE'>13N</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hk7|1hk7]], [[1a4h|1a4h]], [[2bre|2bre]], [[2iws|2iws]], [[2wer|2wer]], [[1usu|1usu]], [[2brc|2brc]], [[1zwh|1zwh]], [[1ah8|1ah8]], [[2vw5|2vw5]], [[2cgf|2cgf]], [[2ygf|2ygf]], [[1am1|1am1]], [[2yge|2yge]], [[2iwx|2iwx]], [[2cge|2cge]], [[1zw9|1zw9]], [[2wep|2wep]], [[2akp|2akp]], [[1us7|1us7]], [[2vwc|2vwc]], [[2cg9|2cg9]], [[2xd6|2xd6]], [[2yga|2yga]], [[1ah6|1ah6]], [[1usv|1usv]], [[1bgq|1bgq]], [[1amw|1amw]], [[2weq|2weq]], [[2xx4|2xx4]], [[2xx2|2xx2]], [[2iwu|2iwu]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hk7|1hk7]], [[1a4h|1a4h]], [[2bre|2bre]], [[2iws|2iws]], [[2wer|2wer]], [[1usu|1usu]], [[2brc|2brc]], [[1zwh|1zwh]], [[1ah8|1ah8]], [[2vw5|2vw5]], [[2cgf|2cgf]], [[2ygf|2ygf]], [[1am1|1am1]], [[2yge|2yge]], [[2iwx|2iwx]], [[2cge|2cge]], [[1zw9|1zw9]], [[2wep|2wep]], [[2akp|2akp]], [[1us7|1us7]], [[2vwc|2vwc]], [[2cg9|2cg9]], [[2xd6|2xd6]], [[2yga|2yga]], [[1ah6|1ah6]], [[1usv|1usv]], [[1bgq|1bgq]], [[1amw|1amw]], [[2weq|2weq]], [[2xx4|2xx4]], [[2xx2|2xx2]], [[2iwu|2iwu]]</td></tr> | ||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xx5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xx5 PDBsum]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[[http://www.uniprot.org/uniprot/HSP82_YEAST HSP82_YEAST]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.<ref>PMID:17114002</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.,Day JE, Sharp SY, Rowlands MG, Aherne W, Hayes A, Raynaud FI, Lewis W, Roe SM, Prodromou C, Pearl LH, Workman P, Moody CJ ACS Chem Biol. 2011 Oct 4. PMID:21932796<ref>PMID:21932796</ref> | Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.,Day JE, Sharp SY, Rowlands MG, Aherne W, Hayes A, Raynaud FI, Lewis W, Roe SM, Prodromou C, Pearl LH, Workman P, Moody CJ ACS Chem Biol. 2011 Oct 4. PMID:21932796<ref>PMID:21932796</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Moody, C J | [[Category: Moody, C J]] | ||
[[Category: Pearl, L H | [[Category: Pearl, L H]] | ||
[[Category: Prodromou, C | [[Category: Prodromou, C]] | ||
[[Category: Roe, S M | [[Category: Roe, S M]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||