1kwt: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kwt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KWT FirstGlance]. <br> | <table><tr><td colspan='2'>[[1kwt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KWT FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kwu|1kwu]], [[1kwv|1kwv]], [[1kww|1kww]], [[1kwx|1kwx]], [[1kwy|1kwy]], [[1kwz|1kwz]], [[1kx0|1kx0]], [[1kx1|1kx1]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kwu|1kwu]], [[1kwv|1kwv]], [[1kww|1kww]], [[1kwx|1kwx]], [[1kwy|1kwy]], [[1kwz|1kwz]], [[1kx0|1kx0]], [[1kx1|1kx1]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kwt RCSB], [http://www.ebi.ac.uk/pdbsum/1kwt PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kwt RCSB], [http://www.ebi.ac.uk/pdbsum/1kwt PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MBL1_RAT MBL1_RAT]] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Clark, D A | [[Category: Clark, D A]] | ||
[[Category: Drickamer, K | [[Category: Drickamer, K]] | ||
[[Category: Feinberg, H | [[Category: Feinberg, H]] | ||
[[Category: Kolatkar, A R | [[Category: Kolatkar, A R]] | ||
[[Category: Ng, K K.S | [[Category: Ng, K K.S]] | ||
[[Category: Park-Snyder, S | [[Category: Park-Snyder, S]] | ||
[[Category: Weis, W I | [[Category: Weis, W I]] | ||
[[Category: C-type lectin]] | [[Category: C-type lectin]] | ||
[[Category: Calcium-binding protein]] | [[Category: Calcium-binding protein]] | ||