2xp8: Difference between revisions
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xp8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xp8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xp8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xp8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 24: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Peptidylprolyl isomerase]] | [[Category: Peptidylprolyl isomerase]] | ||
[[Category: Baker, L | [[Category: Baker, L]] | ||
[[Category: Bryant, C J | [[Category: Bryant, C J]] | ||
[[Category: Davis, B E | [[Category: Davis, B E]] | ||
[[Category: Dokurno, P | [[Category: Dokurno, P]] | ||
[[Category: Fromont, C | [[Category: Fromont, C]] | ||
[[Category: Matossova, N | [[Category: Matossova, N]] | ||
[[Category: Moore, J D | [[Category: Moore, J D]] | ||
[[Category: Murray, J B | [[Category: Murray, J B]] | ||
[[Category: Northfield, C J | [[Category: Northfield, C J]] | ||
[[Category: Nunns, C | [[Category: Nunns, C]] | ||
[[Category: Oldfield, V | [[Category: Oldfield, V]] | ||
[[Category: Potter, A | [[Category: Potter, A]] | ||
[[Category: Ray, S | [[Category: Ray, S]] | ||
[[Category: Richardson, C M | [[Category: Richardson, C M]] | ||
[[Category: Robinson, D | [[Category: Robinson, D]] | ||
[[Category: Scrace, S F | [[Category: Scrace, S F]] | ||
[[Category: Surgenor, A E | [[Category: Surgenor, A E]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Oncogenic transformation]] | [[Category: Oncogenic transformation]] | ||
[[Category: Proline directed kinase]] | [[Category: Proline directed kinase]] | ||